I've always thought that Choros #10 is Villa-Lobos's greatest work. Written in 1926, it's been called Villa's Beethoven 9th Symphony. I remember a special performance of this work conducted by David Robertson, in the Last Night of the Proms concert of 2009. I saw it live via satellite in a Red Deer AB theatre.
My favourite version, though, is the version by John Neschling and OSESP (the Sao Paulo Symphony Orchestra & Chorus).
It's the climax of the great Choros series on 3 CDs from BIS, and also available in a box set along with the equally-great BIS series of Bachianas Brasileiras. You cannot do without these discs!